People

Principal Investigator

Soong Tuck Wah

Title

Professor

Degree

PhD

Research Interests

Investigations into diversification of calcium channel function via alternative splicing and RNA editing and their implications in neurological disorders such as anxiety or fear and in cardiovascular disorders such as hypertension and heart failure. Investigations into physiological significance of alternative splicing and RNA editing of CaV channels in hippocampal learning and memory and cerebellar motor learning, and in feeding behavior and circadian rhythm. Investigations into the implications of functional coupling between galectin-1, galectin-3 or filamin A and Cav1.2 channel in the cardiovascular system, and in heart failure and hypertension.

Office Location

Department of Physiology, Yong Loo Lin School of Medicine, S9, Wet Science Building, S9-11-02A, 4 Science Drive 2, National University of Singapore, S(117544)

Biography

Soong Tuck Wah was the Head of the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, from 2008 to 2017. He was Assistant Dean (Education) from 2006-2008 and is a senior faculty of the LSI Neurobiology Programme and a Principal Investigator of the Healthy Longevity and Cardiovascular Translational Research Programmes.

He has worked in the Imperial Cancer Research Fund, London UK, from 1986-7, and he was a junior research fellow and graduated from the Institute of Molecular and Cell Biology, NUS, in 1992. He was a postdoctoral fellow at the University of British Columbia, Canada, from 1992-5.

He was a visiting scientist at the Johns Hopkins University School of Medicine, USA, from 1999-2000, and was Head and Principal Investigator of the Ion Channel and Transporter Laboratory at the National Neuroscience Institute from 1999-2004.

Selected Publications

  • Huang H, Tay SH, Ng W, Ng SY, Soong TW. Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides. Pain, 2021, Jul 1;162(7):2097-2109. doi:10.1097/j.pain.0000000000002216.
  • Mei Q, Bansal A, Jayakumar MKG, Zhang Z, Zhang J, Huang H, Yu D, Ramachandra CJA, Hausenloy DJ, Soong TW, Zhang Y.
    Manipulating energy migration within single lanthanide activator for Switchable upconversion emissions towards bidirectional photoactivation. Nat Commun. 2019 Sep 27;10(1):4416. doi:10.1038/s41467-019-12374-4.
  • Liu C, Zhang CW, Lo SQ, Ang ST, Chew KCM, Yu D, Chai BH, Tan B, Tsang F, Tai YK, Tan BWQ, Liang MC, Tan HT, Tang JY, Lai MKP, Chua JJE, Chung MCM, Khanna S, Lim KL, Soong TW. S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit. J Neurosci.2018 Sep 26;38(39):8364-8377. doi: 10.1523/JNEUROSCI.3262 17.2018.
  • Hua Huang, Katannya Kapeli, Wenhao Jin, Yuk Peng Wong, Thiruma Valavan Arumugam, Joanne Huifen Koh, Sumitra Srimasorn, Karthik Mallilankaraman, John Jia En Chua, Gene W. Yeo and Tuck Wah Soong Tissue-selective restriction of RNA editing of CaV1.3 by splicing factor SRSF9 Nucleic Acids Res. 2018 Aug 21;46(14):7323-7338. doi: 10.1093/nar/gky348.
  • Hu Z, Li G, Wang JW, Chong SY, Yu D, Wang X, Soon JL, Liang MC, Wong, YP, Huang N, Colecraft HM, Liao P, Soong TW Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction. Circulation. 2018 Oct 2;138(14):1431-1445. doi: 10.1161/CIRCULATIONAHA.117.031231.
  • Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY Jiang F, Yong TF, Wong YP, Hu ZY, Huang H, Zhang G,  Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S and Soong TW Exclusion of alternative exon 33 of CaV1.2 channels in heart is pro arrhythmogenic. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. doi:10.1073/pnas.1617205114.
  • Huang H, Ng CY, Yu D, Zhai J, Lam Y, Soong TW. Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent. Nat Commun. 2014 Jul 24;5:4481.
    doi: 10.1038/ncomms5481. PubMed PMID: 25057870; PubMed Central PMCID: PMC4124865. (Faculty 1000/Prime).
  • Huang H, Tan BZ, Shen Y, Tao J, Jiang F, Sung YY, Ng CK, Raida M, Köhr G, Higuchi M, Fatemi-Shariatpanahi H, Harden B, Yue DT, Soong TW. RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca²⁺-dependent inactivation. Neuron. 2012 Jan 26;73(2):304-16. doi: 10.1016/j.neuron.2011.11.022. PubMed PMID: 22284185; PubMed Central PMCID: PMC3271027. (Faculty 1000/Biology)
  • Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction. Circ Res. 2011 Nov 11;109(11):1250-8. doi: 10.1161/CIRCRESAHA.111.248849. Epub 2011 Oct 13. PubMed PMID: 21998324. 10.47.
  • Ryan DP, da Silva MR, Soong TW, Fontaine B, Donaldson MR, Kung AW, Jongjaroenprasert W, Liang MC, Khoo DH, Cheah JS, Ho SC, Bernstein HS, Maciel RM, Brown RH Jr, Ptácek LJ. Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis. Cell. 2010 Jan 8;140(1):88-98. (Faculty 1000/Biology)