2026
|
Xie, Zongliang; Li, Bowen; Wu, Chongzhi; Li, Zhiyao; Gao, Zhiyuan; Pan, Weidong; Liu, Bin White-Light-Excitable Deep-Red/NIR Organic Afterglow Nanoparticles for
High-Contrast In Vivo Imaging ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2026, DOI: 10.1002/anie.3963775. Abstract | BibTeX | Endnote @article{WOS:001797693200001,
title = {White-Light-Excitable Deep-Red/NIR Organic Afterglow Nanoparticles for
High-Contrast In Vivo Imaging},
author = {Zongliang Xie and Bowen Li and Chongzhi Wu and Zhiyao Li and Zhiyuan Gao and Weidong Pan and Bin Liu},
doi = {10.1002/anie.3963775},
times_cited = {0},
issn = {1433-7851},
year = {2026},
date = {2026-06-01},
journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},
publisher = {WILEY-V C H VERLAG GMBH},
address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
abstract = {Near-infrared (NIR) organic afterglow probes are attractive for
deep-tissue, high-contrast bioimaging, yet simultaneously achieving
white-light excitation, long-lived NIR phosphorescence, and uniform
nanoparticle fabrication remains challenging. Herein, we develop a
bottom-up route to lattice-matched host-guest nanocrystals by
incorporating a rigid phenylcarbazole host (BMC) with scaffold-matched,
extended-conjugation guests (PyC or BPC). The resulting doped crystals
show guest-dominated deep-red/NIR afterglow, with the longest-wavelength
vibronic band reaching 762 nm and can be activated by visible light up
to 475 nm, delivering an ultralong lifetime of 126.1 ms and a
phosphorescence quantum yield of up to 2.7%. Importantly, the intrinsic
homogeneity of the lattice-matched incorporation enables direct
formation of monodisperse phosphorescent nanoparticles via simple
bottom-up nanoprecipitation, avoiding the size heterogeneity and
material loss typically associated with top-down crystal fragmentation.
These nanoparticles exhibit negligible cytotoxicity and deliver bright,
persistent deep-red/NIR emission under white-light excitation for
high-contrast in vivo imaging.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Near-infrared (NIR) organic afterglow probes are attractive for
deep-tissue, high-contrast bioimaging, yet simultaneously achieving
white-light excitation, long-lived NIR phosphorescence, and uniform
nanoparticle fabrication remains challenging. Herein, we develop a
bottom-up route to lattice-matched host-guest nanocrystals by
incorporating a rigid phenylcarbazole host (BMC) with scaffold-matched,
extended-conjugation guests (PyC or BPC). The resulting doped crystals
show guest-dominated deep-red/NIR afterglow, with the longest-wavelength
vibronic band reaching 762 nm and can be activated by visible light up
to 475 nm, delivering an ultralong lifetime of 126.1 ms and a
phosphorescence quantum yield of up to 2.7%. Importantly, the intrinsic
homogeneity of the lattice-matched incorporation enables direct
formation of monodisperse phosphorescent nanoparticles via simple
bottom-up nanoprecipitation, avoiding the size heterogeneity and
material loss typically associated with top-down crystal fragmentation.
These nanoparticles exhibit negligible cytotoxicity and deliver bright,
persistent deep-red/NIR emission under white-light excitation for
high-contrast in vivo imaging. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AFZongliang Xie
Bowen Li
Chongzhi Wu
Zhiyao Li
Zhiyuan Gao
Weidong Pan
Bin Liu
- TIWhite-Light-Excitable Deep-Red/NIR Organic Afterglow Nanoparticles for
High-Contrast In Vivo Imaging - SOANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- DTArticle
- ABNear-infrared (NIR) organic afterglow probes are attractive for
deep-tissue, high-contrast bioimaging, yet simultaneously achieving
white-light excitation, long-lived NIR phosphorescence, and uniform
nanoparticle fabrication remains challenging. Herein, we develop a
bottom-up route to lattice-matched host-guest nanocrystals by
incorporating a rigid phenylcarbazole host (BMC) with scaffold-matched,
extended-conjugation guests (PyC or BPC). The resulting doped crystals
show guest-dominated deep-red/NIR afterglow, with the longest-wavelength
vibronic band reaching 762 nm and can be activated by visible light up
to 475 nm, delivering an ultralong lifetime of 126.1 ms and a
phosphorescence quantum yield of up to 2.7%. Importantly, the intrinsic
homogeneity of the lattice-matched incorporation enables direct
formation of monodisperse phosphorescent nanoparticles via simple
bottom-up nanoprecipitation, avoiding the size heterogeneity and
material loss typically associated with top-down crystal fragmentation.
These nanoparticles exhibit negligible cytotoxicity and deliver bright,
persistent deep-red/NIR emission under white-light excitation for
high-contrast in vivo imaging. - Z90
- PUWILEY-V C H VERLAG GMBH
- PAPOSTFACH 101161, 69451 WEINHEIM, GERMANY
- SN1433-7851
- DI10.1002/anie.3963775
- UTWOS:001797693200001
- ER
- EF
|
Liu, Yong; Song, Wentao; Zhang, Weidong; Liang, Yuanmei; Saini, Mukesh; He, Yuanzhi; Zhu, Jing; Chen, Zhongxin; Zhang, Guoliang; Xie, Jin; Xu, Xiaozhi; Bazan, Guillermo C; Foo, Jee Loon; Chang, Matthew Wook; Liu, Bin; Mao, Xianwen Single-particle imaging uncovers reverse electron transfer efficiency
between Shewanella oneidensis MR-1 and shaped haematite NATURE CATALYSIS, 9 (5), 2026, DOI: 10.1038/s41929-026-01530-x. Abstract | BibTeX | Endnote @article{WOS:001751918400001,
title = {Single-particle imaging uncovers reverse electron transfer efficiency
between Shewanella oneidensis MR-1 and shaped haematite},
author = {Yong Liu and Wentao Song and Weidong Zhang and Yuanmei Liang and Mukesh Saini and Yuanzhi He and Jing Zhu and Zhongxin Chen and Guoliang Zhang and Jin Xie and Xiaozhi Xu and Guillermo C Bazan and Jee Loon Foo and Matthew Wook Chang and Bin Liu and Xianwen Mao},
doi = {10.1038/s41929-026-01530-x},
times_cited = {2},
issn = {2520-1158},
year = {2026},
date = {2026-05-01},
journal = {NATURE CATALYSIS},
volume = {9},
number = {5},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Microbe-semiconductor hybrids hold promise for solar-to-chemical
conversion, but facet-dependent interfacial charge transfer remains
poorly understood due to structural heterogeneity and biological
complexity. Here we leverage a multimodal optical imaging platform to
probe the charge-transfer efficiency between Shewanella oneidensis MR-1
and 110/001-faceted haematite, at single-particle and
single-cell levels, in vivo and operando. We quantify the reverse
extracellular electron-transfer capabilities of Shewanella oneidensis
MR-1 via non-H2-mediated pathways, and identify that haematite's 110
facets synergistically exhibit stronger cell-binding ability and higher
charge-transfer efficiency. Furthermore, we discover that moderate cell
densities are key to enhancing per-cell electron injection, highlighting
the trade-off between total loading and individual cell efficiency, and
offering critical insights into biofilm structure optimization. Our
imaging tools and analytical framework may potentially extend to diverse
microbe-semiconductor hybrid systems, quantifying microscopic structural
and functional descriptors that enhance the fundamental understanding of
complex interfacial charge transfer, and inform rational biohybrid
design across applications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Microbe-semiconductor hybrids hold promise for solar-to-chemical
conversion, but facet-dependent interfacial charge transfer remains
poorly understood due to structural heterogeneity and biological
complexity. Here we leverage a multimodal optical imaging platform to
probe the charge-transfer efficiency between Shewanella oneidensis MR-1
and 110/001-faceted haematite, at single-particle and
single-cell levels, in vivo and operando. We quantify the reverse
extracellular electron-transfer capabilities of Shewanella oneidensis
MR-1 via non-H2-mediated pathways, and identify that haematite's 110
facets synergistically exhibit stronger cell-binding ability and higher
charge-transfer efficiency. Furthermore, we discover that moderate cell
densities are key to enhancing per-cell electron injection, highlighting
the trade-off between total loading and individual cell efficiency, and
offering critical insights into biofilm structure optimization. Our
imaging tools and analytical framework may potentially extend to diverse
microbe-semiconductor hybrid systems, quantifying microscopic structural
and functional descriptors that enhance the fundamental understanding of
complex interfacial charge transfer, and inform rational biohybrid
design across applications. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AFYong Liu
Wentao Song
Weidong Zhang
Yuanmei Liang
Mukesh Saini
Yuanzhi He
Jing Zhu
Zhongxin Chen
Guoliang Zhang
Jin Xie
Xiaozhi Xu
Guillermo C Bazan
Jee Loon Foo
Matthew Wook Chang
Bin Liu
Xianwen Mao
- TISingle-particle imaging uncovers reverse electron transfer efficiency
between Shewanella oneidensis MR-1 and shaped haematite - SONATURE CATALYSIS
- DTArticle
- ABMicrobe-semiconductor hybrids hold promise for solar-to-chemical
conversion, but facet-dependent interfacial charge transfer remains
poorly understood due to structural heterogeneity and biological
complexity. Here we leverage a multimodal optical imaging platform to
probe the charge-transfer efficiency between Shewanella oneidensis MR-1
and 110/001-faceted haematite, at single-particle and
single-cell levels, in vivo and operando. We quantify the reverse
extracellular electron-transfer capabilities of Shewanella oneidensis
MR-1 via non-H2-mediated pathways, and identify that haematite's 110
facets synergistically exhibit stronger cell-binding ability and higher
charge-transfer efficiency. Furthermore, we discover that moderate cell
densities are key to enhancing per-cell electron injection, highlighting
the trade-off between total loading and individual cell efficiency, and
offering critical insights into biofilm structure optimization. Our
imaging tools and analytical framework may potentially extend to diverse
microbe-semiconductor hybrid systems, quantifying microscopic structural
and functional descriptors that enhance the fundamental understanding of
complex interfacial charge transfer, and inform rational biohybrid
design across applications. - Z92
- PUNATURE PORTFOLIO
- PAHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
- SN2520-1158
- VL9
- DI10.1038/s41929-026-01530-x
- UTWOS:001751918400001
- ER
- EF
|
Fang, Yiyun; Zhao, Wen; Xing, Zhilin; Chen, Cheng; Zhou, Xin; Cui, Congcong; Wang, Xuchao; Zheng, Siming; Liu, Qiyuan; Lv, Diandong; Li, Siqi; Chen, Zhaohang; Rong, Zi-Qiang; Guo, Na; Li, Xinzhe; Liu, Bin Asymmetric
Pt1C3-Pt1O1C3
catalytic pairs for efficient transfer hydrogenation of azobenzene NATURE COMMUNICATIONS, 17 (1), 2026, DOI: 10.1038/s41467-026-68759-9. Abstract | BibTeX | Endnote @article{WOS:001714199700004,
title = {Asymmetric
Pt1C3-Pt1O1C3
catalytic pairs for efficient transfer hydrogenation of azobenzene},
author = {Yiyun Fang and Wen Zhao and Zhilin Xing and Cheng Chen and Xin Zhou and Congcong Cui and Xuchao Wang and Siming Zheng and Qiyuan Liu and Diandong Lv and Siqi Li and Zhaohang Chen and Zi-Qiang Rong and Na Guo and Xinzhe Li and Bin Liu},
doi = {10.1038/s41467-026-68759-9},
times_cited = {0},
year = {2026},
date = {2026-02-01},
journal = {NATURE COMMUNICATIONS},
volume = {17},
number = {1},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Atomic catalytic pairs (CPs) have shown great promise in driving
multi-step catalytic transformations, yet the influence of spatial
arrangement and coordination asymmetry on homonuclear CPs remain poorly
understood. Herein, we construct atomically dispersed homonuclear
Pt1-Pt1 CPs with asymmetric Pt1C3-Pt1O1C3 coordination anchored on
reduced graphene oxide. By precisely tuning the spacing between the
adjacent Pt1C3-Pt1O1C3 CPs to approximately 5.3 & Aring;, the catalyst
achieves an exceptional turnover frequency of 27,218 h-1 for transfer
hydrogenation of azobenzene via ammonia-borane hydrolysis, surpassing
benchmarking catalysts by more than an order of magnitude. The
Pt1C3-Pt1O1C3 CPs separated by 5.3 & Aring; can facilitate
co-adsorption of sterically hindered intermediates and at the same time
the asymmetric Pt1C3-Pt1O1C3 coordination enables facile hydrogen
shuttling and barrier-suppressed hydrogenation. These synergistic
effects enhance the overall azobenzene hydrogenation efficiency. Our
findings uncover a fundamental spatial design principle for atomically
precise homonuclear asymmetric CPs, offering new opportunities for
sustainable and efficient fine chemical synthesis.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Atomic catalytic pairs (CPs) have shown great promise in driving
multi-step catalytic transformations, yet the influence of spatial
arrangement and coordination asymmetry on homonuclear CPs remain poorly
understood. Herein, we construct atomically dispersed homonuclear
Pt1-Pt1 CPs with asymmetric Pt1C3-Pt1O1C3 coordination anchored on
reduced graphene oxide. By precisely tuning the spacing between the
adjacent Pt1C3-Pt1O1C3 CPs to approximately 5.3 & Aring;, the catalyst
achieves an exceptional turnover frequency of 27,218 h-1 for transfer
hydrogenation of azobenzene via ammonia-borane hydrolysis, surpassing
benchmarking catalysts by more than an order of magnitude. The
Pt1C3-Pt1O1C3 CPs separated by 5.3 & Aring; can facilitate
co-adsorption of sterically hindered intermediates and at the same time
the asymmetric Pt1C3-Pt1O1C3 coordination enables facile hydrogen
shuttling and barrier-suppressed hydrogenation. These synergistic
effects enhance the overall azobenzene hydrogenation efficiency. Our
findings uncover a fundamental spatial design principle for atomically
precise homonuclear asymmetric CPs, offering new opportunities for
sustainable and efficient fine chemical synthesis. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AFYiyun Fang
Wen Zhao
Zhilin Xing
Cheng Chen
Xin Zhou
Congcong Cui
Xuchao Wang
Siming Zheng
Qiyuan Liu
Diandong Lv
Siqi Li
Zhaohang Chen
Zi-Qiang Rong
Na Guo
Xinzhe Li
Bin Liu
- TIAsymmetric
Pt1C3-Pt1O1C3
catalytic pairs for efficient transfer hydrogenation of azobenzene - SONATURE COMMUNICATIONS
- DTArticle
- ABAtomic catalytic pairs (CPs) have shown great promise in driving
multi-step catalytic transformations, yet the influence of spatial
arrangement and coordination asymmetry on homonuclear CPs remain poorly
understood. Herein, we construct atomically dispersed homonuclear
Pt1-Pt1 CPs with asymmetric Pt1C3-Pt1O1C3 coordination anchored on
reduced graphene oxide. By precisely tuning the spacing between the
adjacent Pt1C3-Pt1O1C3 CPs to approximately 5.3 & Aring;, the catalyst
achieves an exceptional turnover frequency of 27,218 h-1 for transfer
hydrogenation of azobenzene via ammonia-borane hydrolysis, surpassing
benchmarking catalysts by more than an order of magnitude. The
Pt1C3-Pt1O1C3 CPs separated by 5.3 & Aring; can facilitate
co-adsorption of sterically hindered intermediates and at the same time
the asymmetric Pt1C3-Pt1O1C3 coordination enables facile hydrogen
shuttling and barrier-suppressed hydrogenation. These synergistic
effects enhance the overall azobenzene hydrogenation efficiency. Our
findings uncover a fundamental spatial design principle for atomically
precise homonuclear asymmetric CPs, offering new opportunities for
sustainable and efficient fine chemical synthesis. - Z90
- PUNATURE PORTFOLIO
- PAHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
- VL17
- DI10.1038/s41467-026-68759-9
- UTWOS:001714199700004
- ER
- EF
|
2025
|
Xue, Yufeng; Xie, Zongliang; Yin, Zheng; Xu, Yincai; Liu, Bin Full-color processible afterglow organic small molecular glass 23 NATURE COMMUNICATIONS, 16 (1), 2025, DOI: 10.1038/s41467-025-59787-y. Abstract | BibTeX | Endnote @article{WOS:001489557900028,
title = {Full-color processible afterglow organic small molecular glass},
author = {Yufeng Xue and Zongliang Xie and Zheng Yin and Yincai Xu and Bin Liu},
doi = {10.1038/s41467-025-59787-y},
times_cited = {23},
year = {2025},
date = {2025-05-01},
journal = {NATURE COMMUNICATIONS},
volume = {16},
number = {1},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Organic afterglow materials, known for their unique luminescent
properties and diverse applications, have garnered significant attention
in recent years. However, developing long-lasting, high-efficiency,
full-color afterglow systems and exploring simple materials processing
strategies for new applications are still challenging in this field.
Herein, we rationally design a processable molecular glass and employ it
as a host in a host-guest strategy to address these challenges. By
strategically modifying the host via othyl-methylation, we successfully
create a molecular glass and capture its temperature-dependent,
processable viscous supercooled liquid state. High-efficiency full color
from violet to near-infrared afterglow systems with ultralong lifetimes
are developed by doping varied structural dopants. The underlying
glass-forming and afterglow mechanisms are also clearly elucidated and
verified. Moreover, the excellent glass-forming ability of the host and
its viscous supercooled liquid enabled the glass system for large-area
fabrication, shaping of objects with diverse 3D structures, and creation
of flexible, meter-long afterglow fibers. This work offers significant
potential for practical applications in advanced textiles, displays, and
other fields.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Organic afterglow materials, known for their unique luminescent
properties and diverse applications, have garnered significant attention
in recent years. However, developing long-lasting, high-efficiency,
full-color afterglow systems and exploring simple materials processing
strategies for new applications are still challenging in this field.
Herein, we rationally design a processable molecular glass and employ it
as a host in a host-guest strategy to address these challenges. By
strategically modifying the host via othyl-methylation, we successfully
create a molecular glass and capture its temperature-dependent,
processable viscous supercooled liquid state. High-efficiency full color
from violet to near-infrared afterglow systems with ultralong lifetimes
are developed by doping varied structural dopants. The underlying
glass-forming and afterglow mechanisms are also clearly elucidated and
verified. Moreover, the excellent glass-forming ability of the host and
its viscous supercooled liquid enabled the glass system for large-area
fabrication, shaping of objects with diverse 3D structures, and creation
of flexible, meter-long afterglow fibers. This work offers significant
potential for practical applications in advanced textiles, displays, and
other fields. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AFYufeng Xue
Zongliang Xie
Zheng Yin
Yincai Xu
Bin Liu
- TIFull-color processible afterglow organic small molecular glass
- SONATURE COMMUNICATIONS
- DTArticle
- ABOrganic afterglow materials, known for their unique luminescent
properties and diverse applications, have garnered significant attention
in recent years. However, developing long-lasting, high-efficiency,
full-color afterglow systems and exploring simple materials processing
strategies for new applications are still challenging in this field.
Herein, we rationally design a processable molecular glass and employ it
as a host in a host-guest strategy to address these challenges. By
strategically modifying the host via othyl-methylation, we successfully
create a molecular glass and capture its temperature-dependent,
processable viscous supercooled liquid state. High-efficiency full color
from violet to near-infrared afterglow systems with ultralong lifetimes
are developed by doping varied structural dopants. The underlying
glass-forming and afterglow mechanisms are also clearly elucidated and
verified. Moreover, the excellent glass-forming ability of the host and
its viscous supercooled liquid enabled the glass system for large-area
fabrication, shaping of objects with diverse 3D structures, and creation
of flexible, meter-long afterglow fibers. This work offers significant
potential for practical applications in advanced textiles, displays, and
other fields. - Z923
- PUNATURE PORTFOLIO
- PAHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
- VL16
- DI10.1038/s41467-025-59787-y
- UTWOS:001489557900028
- ER
- EF
|
Qi, Guobin; Liu, Xianglong; Li, Hao; Qian, Yunyun; Liu, Can; Zhuang, Jiahao; Shi, Leilei; Liu, Bin A dual-mechanism luminescent antibiotic for bacterial infection
identification and eradication 11 SCIENCE ADVANCES, 11 (15), 2025, DOI: 10.1126/sciadv.adp9448. Abstract | BibTeX | Endnote @article{WOS:001464913900002,
title = {A dual-mechanism luminescent antibiotic for bacterial infection
identification and eradication},
author = {Guobin Qi and Xianglong Liu and Hao Li and Yunyun Qian and Can Liu and Jiahao Zhuang and Leilei Shi and Bin Liu},
doi = {10.1126/sciadv.adp9448},
times_cited = {11},
issn = {2375-2548},
year = {2025},
date = {2025-04-01},
journal = {SCIENCE ADVANCES},
volume = {11},
number = {15},
publisher = {AMER ASSOC ADVANCEMENT SCIENCE},
address = {1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA},
abstract = {Because of the rapid emergence of antibiotic-resistant bacteria, there
is a growing need to discover antibacterial agents. Here, we design and
synthesize a compound of TPA2PyBu that kills both Gram-negative and
Gram-positive bacteria with an undetectably low drug resistance.
Comprehensive analyses reveal that the antimicrobial activity of
TPA2PyBu proceeds via a unique dual mechanism by damaging bacterial
membrane integrity and inducing DNA aggregation. TPA2PyBu could provide
imaging specificity that differentiates bacterial infection from
inflammation and cancer. High in vivo treatment efficacy of TPA2PyBu was
achieved in methicillin-resistant Staphylococcus aureus infection mouse
models. This promising antimicrobial agent suggests that combining
multiple mechanisms of action into a single molecule can be an effective
approach to address challenging bacterial infections.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Because of the rapid emergence of antibiotic-resistant bacteria, there
is a growing need to discover antibacterial agents. Here, we design and
synthesize a compound of TPA2PyBu that kills both Gram-negative and
Gram-positive bacteria with an undetectably low drug resistance.
Comprehensive analyses reveal that the antimicrobial activity of
TPA2PyBu proceeds via a unique dual mechanism by damaging bacterial
membrane integrity and inducing DNA aggregation. TPA2PyBu could provide
imaging specificity that differentiates bacterial infection from
inflammation and cancer. High in vivo treatment efficacy of TPA2PyBu was
achieved in methicillin-resistant Staphylococcus aureus infection mouse
models. This promising antimicrobial agent suggests that combining
multiple mechanisms of action into a single molecule can be an effective
approach to address challenging bacterial infections. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AFGuobin Qi
Xianglong Liu
Hao Li
Yunyun Qian
Can Liu
Jiahao Zhuang
Leilei Shi
Bin Liu
- TIA dual-mechanism luminescent antibiotic for bacterial infection
identification and eradication - SOSCIENCE ADVANCES
- DTArticle
- ABBecause of the rapid emergence of antibiotic-resistant bacteria, there
is a growing need to discover antibacterial agents. Here, we design and
synthesize a compound of TPA2PyBu that kills both Gram-negative and
Gram-positive bacteria with an undetectably low drug resistance.
Comprehensive analyses reveal that the antimicrobial activity of
TPA2PyBu proceeds via a unique dual mechanism by damaging bacterial
membrane integrity and inducing DNA aggregation. TPA2PyBu could provide
imaging specificity that differentiates bacterial infection from
inflammation and cancer. High in vivo treatment efficacy of TPA2PyBu was
achieved in methicillin-resistant Staphylococcus aureus infection mouse
models. This promising antimicrobial agent suggests that combining
multiple mechanisms of action into a single molecule can be an effective
approach to address challenging bacterial infections. - Z911
- PUAMER ASSOC ADVANCEMENT SCIENCE
- PA1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
- SN2375-2548
- VL11
- DI10.1126/sciadv.adp9448
- UTWOS:001464913900002
- ER
- EF
|