2024
|
Liu, Xianglong; Li, Hao; Qi, Guobin; Qian, Yunyun; Li, Bowen; Shi, Leilei; Liu, Bin Combating Fungal Infections and Resistance with a Dual-Mechanism Luminogen to Disrupt Membrane Integrity and Induce DNA Damage JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, DOI: 10.1021/jacs.4c09916. Abstract | BibTeX | Endnote @article{ISI:001349082400001,
title = {Combating Fungal Infections and Resistance with a Dual-Mechanism Luminogen to Disrupt Membrane Integrity and Induce DNA Damage},
author = {Xianglong Liu and Hao Li and Guobin Qi and Yunyun Qian and Bowen Li and Leilei Shi and Bin Liu},
doi = {10.1021/jacs.4c09916},
times_cited = {0},
issn = {0002-7863},
year = {2024},
date = {2024-11-06},
journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},
publisher = {AMER CHEMICAL SOC},
address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
abstract = {Antifungal drug resistance is a critical concern, demanding innovative therapeutic solutions. The dual-targeting mechanism of action (MoA), as an effective strategy to reduce drug resistance, has been validated in the design of antibacterial agents. However, the structural similarities between mammalian and fungal cells complicate the development of such a strategy for antifungal agents as the selectivity can be compromised. Herein, we introduce a dual-targeting strategy addressing fungal infections by selectively introducing DNA binding molecules into fungal nuclei. We incorporate rigid hydrophobic units into a DNA-binding domain to fabricate antifungal luminogens of TPY and TPZ, which exhibit enhanced membrane penetration and DNA-binding capabilities. These compounds exhibit dual-targeting MoA by depolarizing fungal membranes and inducing DNA damage, amplifying their potency against fungal pathogens with undetectable drug resistance. TPY and TPZ demonstrated robust antifungal activity in vitro and exhibited ideal therapeutic efficacy in a murine model of C. albicans-induced vaginitis. This multifaceted approach holds promise for overcoming drug resistance and advancing antifungal therapy.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Antifungal drug resistance is a critical concern, demanding innovative therapeutic solutions. The dual-targeting mechanism of action (MoA), as an effective strategy to reduce drug resistance, has been validated in the design of antibacterial agents. However, the structural similarities between mammalian and fungal cells complicate the development of such a strategy for antifungal agents as the selectivity can be compromised. Herein, we introduce a dual-targeting strategy addressing fungal infections by selectively introducing DNA binding molecules into fungal nuclei. We incorporate rigid hydrophobic units into a DNA-binding domain to fabricate antifungal luminogens of TPY and TPZ, which exhibit enhanced membrane penetration and DNA-binding capabilities. These compounds exhibit dual-targeting MoA by depolarizing fungal membranes and inducing DNA damage, amplifying their potency against fungal pathogens with undetectable drug resistance. TPY and TPZ demonstrated robust antifungal activity in vitro and exhibited ideal therapeutic efficacy in a murine model of C. albicans-induced vaginitis. This multifaceted approach holds promise for overcoming drug resistance and advancing antifungal therapy. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AULiu, XL
Li, H
Qi, GB
Qian, YY
Li, BW
Shi, LL
Liu, B
- AFXianglong Liu
Hao Li
Guobin Qi
Yunyun Qian
Bowen Li
Leilei Shi
Bin Liu
- TICombating Fungal Infections and Resistance with a Dual-Mechanism Luminogen to Disrupt Membrane Integrity and Induce DNA Damage
- SOJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- LAEnglish
- DTArticle
- IDIN-VITRO ACTIVITY; ANTIFUNGAL; INHIBITOR; THREAT; DRUG
- ABAntifungal drug resistance is a critical concern, demanding innovative therapeutic solutions. The dual-targeting mechanism of action (MoA), as an effective strategy to reduce drug resistance, has been validated in the design of antibacterial agents. However, the structural similarities between mammalian and fungal cells complicate the development of such a strategy for antifungal agents as the selectivity can be compromised. Herein, we introduce a dual-targeting strategy addressing fungal infections by selectively introducing DNA binding molecules into fungal nuclei. We incorporate rigid hydrophobic units into a DNA-binding domain to fabricate antifungal luminogens of TPY and TPZ, which exhibit enhanced membrane penetration and DNA-binding capabilities. These compounds exhibit dual-targeting MoA by depolarizing fungal membranes and inducing DNA damage, amplifying their potency against fungal pathogens with undetectable drug resistance. TPY and TPZ demonstrated robust antifungal activity in vitro and exhibited ideal therapeutic efficacy in a murine model of C. albicans-induced vaginitis. This multifaceted approach holds promise for overcoming drug resistance and advancing antifungal therapy.
- C1[Liu, Xianglong; Qi, Guobin; Li, Bowen; Liu, Bin] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore.
[Liu, Xianglong; Liu, Bin] Natl Univ Singapore, Joint Sch, Int Campus, Fuzhou 350207, Peoples R China. [Liu, Xianglong; Liu, Bin] Tianjin Univ, Int Campus, Fuzhou 350207, Peoples R China. [Li, Hao; Qian, Yunyun] Xiamen Univ, Xiangan Hosp, Sch Med, Dept Organ Transplantat, Xiamen 361005, Fujian, Peoples R China. [Qi, Guobin] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Key Lab Biopharmaceut Preparat & Delivery, Beijing 100190, Peoples R China. [Shi, Leilei] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 200025, Peoples R China. [Liu, Bin] Natl Univ Singapore Singapore, Inst Funct Intelligent Mat, Singapore 117544, Singapore - C3National University of Singapore; National University of Singapore; Tianjin University; Xiamen University; Chinese Academy of Sciences; Institute of Process Engineering, CAS; Shanghai Jiao Tong University; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore
- RPLiu, B (corresponding author), Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore; Liu, B (corresponding author), Natl Univ Singapore, Joint Sch, Int Campus, Fuzhou 350207, Peoples R China; Liu, B (corresponding author), Tianjin Univ, Int Campus, Fuzhou 350207, Peoples R China; Shi, LL (corresponding author), Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 200025, Peoples R China; Liu, B (corresponding author), Natl Univ Singapore Singapore, Inst Funct Intelligent Mat, Singapore 117544, Singapore
- FUNational University of Singapore [A-0001423-06-00]; National University of Singapore [A-0009163-01-00, E-467-00-0012-02]; Singapore National Research Foundation [22105229]; National Natural Science Foundation of China
- FXThis study is supported by the National University of Singapore (A-0001423-06-00), the Singapore National Research Foundation (A-0009163-01-00; E-467-00-0012-02), and the National Natural Science Foundation of China (22105229).
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- U21
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- SN0002-7863
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- JIJ. Am. Chem. Soc.
- PDNOV 6
- PY2024
- DI10.1021/jacs.4c09916
- PG9
- WCChemistry, Multidisciplinary
- SCChemistry
- GAL2L3J
- UTWOS:001349082400001
- ER
- EF
|
Chen, Junru; Zhang, Xianhe; Xie, Zongliang; Liu, Bin Ultralong thermally activated delayed fluorescence based on intermolecular charge transfer induced by isomer in carbazole derivative AGGREGATE, 2024, DOI: 10.1002/agt2.638. Abstract | BibTeX | Endnote @article{ISI:001282370100001,
title = {Ultralong thermally activated delayed fluorescence based on intermolecular charge transfer induced by isomer in carbazole derivative},
author = {Junru Chen and Xianhe Zhang and Zongliang Xie and Bin Liu},
doi = {10.1002/agt2.638},
times_cited = {0},
year = {2024},
date = {2024-08-02},
journal = {AGGREGATE},
publisher = {WILEY},
address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
abstract = {Ultralong thermally activated delayed fluorescence (UTADF) materials play an important role in realizing time-dependent color-tunable afterglow. Some typical carbazole (Cz) derivatives have been reported to exhibit UTADF properties. However, a 10-fold difference in TADF lifetime was found between commercial Cz derivatives and the corresponding lab-synthesized ones, which indicated that UTADF may not be derived from the single Cz derivatives as reported. To reveal the real mechanism, we synthesized three Cz derivatives and one isomer to form three host-guest pairs for optical studies. The photophysical properties revealed that UTADF originated from the intermolecular charge transfer between host and guest, while the ultralong organic phosphorescence was from the guest. Thanks to the rich color variations in luminescence displayed by 4-(1H-benzo[f]indol-1-yl)-4 '-(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile/4,4 '-di(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile (CBP-2CN) at different delay times, it can be applied to realize multi-dimensional encryption in both delay time and luminescent color.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Ultralong thermally activated delayed fluorescence (UTADF) materials play an important role in realizing time-dependent color-tunable afterglow. Some typical carbazole (Cz) derivatives have been reported to exhibit UTADF properties. However, a 10-fold difference in TADF lifetime was found between commercial Cz derivatives and the corresponding lab-synthesized ones, which indicated that UTADF may not be derived from the single Cz derivatives as reported. To reveal the real mechanism, we synthesized three Cz derivatives and one isomer to form three host-guest pairs for optical studies. The photophysical properties revealed that UTADF originated from the intermolecular charge transfer between host and guest, while the ultralong organic phosphorescence was from the guest. Thanks to the rich color variations in luminescence displayed by 4-(1H-benzo[f]indol-1-yl)-4 '-(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile/4,4 '-di(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile (CBP-2CN) at different delay times, it can be applied to realize multi-dimensional encryption in both delay time and luminescent color. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AUChen, JR
Zhang, XH
Xie, ZL
Liu, B
- AFJunru Chen
Xianhe Zhang
Zongliang Xie
Bin Liu
- TIUltralong thermally activated delayed fluorescence based on intermolecular charge transfer induced by isomer in carbazole derivative
- SOAGGREGATE
- LAEnglish
- DTArticle
- DEEnergy Transfer; Intermolecular Charge Transfer; Ultralong Organic Phosphorescence; Ultralong Thermally Activated Delayed Fluorescence
- IDAFTERGLOW; DIFFUSION; STATE
- ABUltralong thermally activated delayed fluorescence (UTADF) materials play an important role in realizing time-dependent color-tunable afterglow. Some typical carbazole (Cz) derivatives have been reported to exhibit UTADF properties. However, a 10-fold difference in TADF lifetime was found between commercial Cz derivatives and the corresponding lab-synthesized ones, which indicated that UTADF may not be derived from the single Cz derivatives as reported. To reveal the real mechanism, we synthesized three Cz derivatives and one isomer to form three host-guest pairs for optical studies. The photophysical properties revealed that UTADF originated from the intermolecular charge transfer between host and guest, while the ultralong organic phosphorescence was from the guest. Thanks to the rich color variations in luminescence displayed by 4-(1H-benzo[f]indol-1-yl)-4 '-(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile/4,4 '-di(9H-carbazol-9-yl)-[1,1 '-biphenyl]-3,3 '-dicarbonitrile (CBP-2CN) at different delay times, it can be applied to realize multi-dimensional encryption in both delay time and luminescent color.
- C1[Chen, Junru; Zhang, Xianhe; Xie, Zongliang; Liu, Bin] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore.
[Zhang, Xianhe; Liu, Bin] Natl Univ Singapore, NUS Grad Sch, Integrat Sci & Engn Program, Singapore, Singapore. [Xie, Zongliang; Liu, Bin] Natl Univ Singapore, Inst Funct Intelligent Mat, Singapore, Singapore - C3National University of Singapore; National University of Singapore; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM)
- RPLiu, B (corresponding author), Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore
- FUNational University of Singapore [A-0001423-06-00]; Singapore National Research Foundation [A-0009163-01-00]
- FXNational University of Singapore, Grant/Award Number: A-0001423-06-00; The Singapore National Research Foundation, Grant/Award Number: A-0009163-01-00.
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- TC0
- Z90
- U17
- U27
- PUWILEY
- PIHOBOKEN
- PA111 RIVER ST, HOBOKEN 07030-5774, NJ USA
- J9AGGREGATE
- JIAggregate
- PDAUG 2
- PY2024
- DI10.1002/agt2.638
- PG8
- WCChemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary
- SCChemistry; Materials Science
- GAA4P5N
- UTWOS:001282370100001
- ER
- EF
|
Xie, Zongliang; Xue, Yufeng; Zhang, Xianhe; Chen, Junru; Lin, Zesen; Liu, Bin Isostructural doping for organic persistent mechanoluminescence NATURE COMMUNICATIONS, 15 (1), 2024, DOI: 10.1038/s41467-024-47962-6. Abstract | BibTeX | Endnote @article{ISI:001267004700001,
title = {Isostructural doping for organic persistent mechanoluminescence},
author = {Zongliang Xie and Yufeng Xue and Xianhe Zhang and Junru Chen and Zesen Lin and Bin Liu},
doi = {10.1038/s41467-024-47962-6},
times_cited = {1},
year = {2024},
date = {2024-04-30},
journal = {NATURE COMMUNICATIONS},
volume = {15},
number = {1},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Mechanoluminescence, featuring light emission triggered by mechanical stimuli, holds immense promise for diverse applications. However, most organic Mechanoluminescence materials suffer from short-lived luminescence, limiting their practical applications. Herein, we report isostructural doping as a valuable strategy to address this challenge. By strategically modifying the host matrices with specific functional groups and simultaneously engineering guest molecules with structurally analogous features for isostructural doping, we have successfully achieved diverse multicolor and high-efficiency persistent mechanoluminescence materials with ultralong lifetimes. The underlying persistent mechanoluminescence mechanism and the universality of the isostructural doping strategy are also clearly elucidated and verified. Moreover, stress sensing devices are fabricated to show their promising prospects in high-resolution optical storage, pressure-sensitive displays, and stress monitoring. This work may facilitate the development of highly efficient organic persistent mechanoluminescence materials, expanding the horizons of next-generation smart luminescent technologies.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Mechanoluminescence, featuring light emission triggered by mechanical stimuli, holds immense promise for diverse applications. However, most organic Mechanoluminescence materials suffer from short-lived luminescence, limiting their practical applications. Herein, we report isostructural doping as a valuable strategy to address this challenge. By strategically modifying the host matrices with specific functional groups and simultaneously engineering guest molecules with structurally analogous features for isostructural doping, we have successfully achieved diverse multicolor and high-efficiency persistent mechanoluminescence materials with ultralong lifetimes. The underlying persistent mechanoluminescence mechanism and the universality of the isostructural doping strategy are also clearly elucidated and verified. Moreover, stress sensing devices are fabricated to show their promising prospects in high-resolution optical storage, pressure-sensitive displays, and stress monitoring. This work may facilitate the development of highly efficient organic persistent mechanoluminescence materials, expanding the horizons of next-generation smart luminescent technologies. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AUXie, ZL
Xue, YF
Zhang, XH
Chen, JR
Lin, ZS
Liu, B
- AFZongliang Xie
Yufeng Xue
Xianhe Zhang
Junru Chen
Zesen Lin
Bin Liu
- TIIsostructural doping for organic persistent mechanoluminescence
- SONATURE COMMUNICATIONS
- LAEnglish
- DTArticle
- IDPHOSPHORESCENCE
- ABMechanoluminescence, featuring light emission triggered by mechanical stimuli, holds immense promise for diverse applications. However, most organic Mechanoluminescence materials suffer from short-lived luminescence, limiting their practical applications. Herein, we report isostructural doping as a valuable strategy to address this challenge. By strategically modifying the host matrices with specific functional groups and simultaneously engineering guest molecules with structurally analogous features for isostructural doping, we have successfully achieved diverse multicolor and high-efficiency persistent mechanoluminescence materials with ultralong lifetimes. The underlying persistent mechanoluminescence mechanism and the universality of the isostructural doping strategy are also clearly elucidated and verified. Moreover, stress sensing devices are fabricated to show their promising prospects in high-resolution optical storage, pressure-sensitive displays, and stress monitoring. This work may facilitate the development of highly efficient organic persistent mechanoluminescence materials, expanding the horizons of next-generation smart luminescent technologies.
- C3Institute for Functional Intelligent Materials (I-FIM); National University of Singapore; National University of Singapore
- RPLiu, B (corresponding author), Natl Univ Singapore, Inst Funct Intelligent Mat, Singapore, Singapore; Liu, B (corresponding author), Natl Univ Singapore, Dept Chem & BioMol Engn, Singapore, Singapore
- FXThis study was supported by the Singapore National Research Foundation Investigatorship (A-8002259-00-00, B.L.), the Singapore Ministry of Education: Research Center of Excellence (A-0001423-06-00, B.L.), and the National University of Singapore (E-467-00-0032-01, B.L.). Thanks to Yi Shan for assisting in capturing the confocal fluorescence images.
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- TC1
- Z91
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- U242
- PUNATURE PORTFOLIO
- PIBERLIN
- PAHEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
- J9NAT COMMUN
- JINat. Commun.
- PDAPR 30
- PY2024
- VL15
- DI10.1038/s41467-024-47962-6
- PG8
- WCMultidisciplinary Sciences
- SCScience & Technology - Other Topics
- GAYF2L9
- UTWOS:001267004700001
- ER
- EF
|
2023
|
Qi, Guobin; Liu, Xianglong; Shi, Leilei; Zhuang, Jiahao; Liu, Bin Targeted Depletion of Individual Pathogen by Bacteria-Templated Polymer ADVANCED MATERIALS, 36 (7), 2023, DOI: 10.1002/adma.202307940. Abstract | BibTeX | Endnote @article{ISI:001114728300001,
title = {Targeted Depletion of Individual Pathogen by Bacteria-Templated Polymer},
author = {Guobin Qi and Xianglong Liu and Leilei Shi and Jiahao Zhuang and Bin Liu},
doi = {10.1002/adma.202307940},
times_cited = {0},
issn = {0935-9648},
year = {2023},
date = {2023-12-07},
journal = {ADVANCED MATERIALS},
volume = {36},
number = {7},
publisher = {WILEY-V C H VERLAG GMBH},
address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
abstract = {Selective and targeted removal of individual species or strains of bacteria from complex communities can be desirable over traditional and broadly acting antibiotics in several conditions. However, strategies that can detect and ablate bacteria with high specificity are emerging in recent years. Herein, a platform is reported that uses bacteria as a template to synthesize polymers containing guanidinium groups for self-selective depletion of specific pathogenic bacteria without disturbing microbial communities. Different from conventional antibiotics, repeated treatment of bacteria with the templated polymers does not evolve drug resistance mutants after 20 days of serial passaging. Especially, high in vivo therapeutic effectiveness of the templated polymers is achieved in E. coli- and P. aeruginosa-induced microbial peritonitis. The templated polymers have shown high selectivity in in vivo antimicrobial activity, which has excellent potential as systemic antimicrobials against bacterial infections.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
Selective and targeted removal of individual species or strains of bacteria from complex communities can be desirable over traditional and broadly acting antibiotics in several conditions. However, strategies that can detect and ablate bacteria with high specificity are emerging in recent years. Herein, a platform is reported that uses bacteria as a template to synthesize polymers containing guanidinium groups for self-selective depletion of specific pathogenic bacteria without disturbing microbial communities. Different from conventional antibiotics, repeated treatment of bacteria with the templated polymers does not evolve drug resistance mutants after 20 days of serial passaging. Especially, high in vivo therapeutic effectiveness of the templated polymers is achieved in E. coli- and P. aeruginosa-induced microbial peritonitis. The templated polymers have shown high selectivity in in vivo antimicrobial activity, which has excellent potential as systemic antimicrobials against bacterial infections. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AUQi, GB
Liu, XL
Shi, LL
Zhuang, JH
Liu, B
- AFGuobin Qi
Xianglong Liu
Leilei Shi
Jiahao Zhuang
Bin Liu
- TITargeted Depletion of Individual Pathogen by Bacteria-Templated Polymer
- SOADVANCED MATERIALS
- LAEnglish
- DTArticle
- DEATRP; Bacterial Infection; Bacteria-templated Polymer; Target Depletion
- IDMICROBIOME; HEALTH
- ABSelective and targeted removal of individual species or strains of bacteria from complex communities can be desirable over traditional and broadly acting antibiotics in several conditions. However, strategies that can detect and ablate bacteria with high specificity are emerging in recent years. Herein, a platform is reported that uses bacteria as a template to synthesize polymers containing guanidinium groups for self-selective depletion of specific pathogenic bacteria without disturbing microbial communities. Different from conventional antibiotics, repeated treatment of bacteria with the templated polymers does not evolve drug resistance mutants after 20 days of serial passaging. Especially, high in vivo therapeutic effectiveness of the templated polymers is achieved in E. coli- and P. aeruginosa-induced microbial peritonitis. The templated polymers have shown high selectivity in in vivo antimicrobial activity, which has excellent potential as systemic antimicrobials against bacterial infections.
- C3National University of Singapore; Tianjin University; Shanghai Jiao Tong University; Institute for Functional Intelligent Materials (I-FIM); National University of Singapore
- RPLiu, B (corresponding author), Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore; Liu, B (corresponding author), Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ Int C, Fuzhou 350207, Peoples R China; Liu, B (corresponding author), Natl Univ Singapore, Inst Funct Intelligent Mat, Blk S9,Level 9,4 Sci Dr 2, Singapore 117544, Singapore
- FXG.Q. and X.L. contributed equally to this work. This study was supported by the National University of Singapore (No. A-0001423-06-00), the Singapore National Research Foundation (No. A-000916-01-00), and the National Natural Science Foundation of China (No. 22105229).
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- SN0935-9648
- J9ADVAN MATER
- JIAdv. Mater.
- PDFEB
- PY2024
- VL36
- DI10.1002/adma.202307940
- PG9
- WCChemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
- SCChemistry; Science & Technology - Other Topics; Materials Science; Physics
- GALV5K0
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|
Qi, Guobin; Tang, Yufu; Shi, Leilei; Zhuang, Jiahao; Liu, Xianglong; Liu, Bin Capsule Shedding and Membrane Binding Enhanced Photodynamic Killing of Gram-Negative Bacteria by a Unimolecular Conjugated Polyelectrolyte NANO LETTERS, 23 (22), pp. 10374-10382, 2023, DOI: 10.1021/acs.nanolett.3c02965. Abstract | BibTeX | Endnote @article{ISI:001108509100001,
title = {Capsule Shedding and Membrane Binding Enhanced Photodynamic Killing of Gram-Negative Bacteria by a Unimolecular Conjugated Polyelectrolyte},
author = {Guobin Qi and Yufu Tang and Leilei Shi and Jiahao Zhuang and Xianglong Liu and Bin Liu},
doi = {10.1021/acs.nanolett.3c02965},
times_cited = {3},
issn = {1530-6984},
year = {2023},
date = {2023-11-03},
journal = {NANO LETTERS},
volume = {23},
number = {22},
pages = {10374-10382},
publisher = {AMER CHEMICAL SOC},
address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
abstract = {The development of new antimicrobial agents to treat infections caused by Gram-negative bacteria is of paramount importance due to increased antibiotic resistance worldwide. Herein, we show that a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte (PorHP) exhibits high photodynamic bactericidal activity against the Gram-negative bacteria tested, including a multidrug-resistant (MDR) pathogen, while demonstrating low cytotoxicity toward mammalian cells. Comprehensive analyses reveal that the antimicrobial activity of PorHP proceeds via a multimodal mechanism by effective bacterial capsule shedding, strong bacterial outer membrane binding, and singlet oxygen generation. Through this multimodal antimicrobial mechanism, PorHP displays significant performance for Gram-negative bacteria with >99.9% photodynamic killing efficacy. Overall, PorHP shows great potential as an antimicrobial agent in fighting the growing threat of Gram-negative bacteria.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}
The development of new antimicrobial agents to treat infections caused by Gram-negative bacteria is of paramount importance due to increased antibiotic resistance worldwide. Herein, we show that a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte (PorHP) exhibits high photodynamic bactericidal activity against the Gram-negative bacteria tested, including a multidrug-resistant (MDR) pathogen, while demonstrating low cytotoxicity toward mammalian cells. Comprehensive analyses reveal that the antimicrobial activity of PorHP proceeds via a multimodal mechanism by effective bacterial capsule shedding, strong bacterial outer membrane binding, and singlet oxygen generation. Through this multimodal antimicrobial mechanism, PorHP displays significant performance for Gram-negative bacteria with >99.9% photodynamic killing efficacy. Overall, PorHP shows great potential as an antimicrobial agent in fighting the growing threat of Gram-negative bacteria. - FNClarivate Analytics Web of Science
- VR1.0
- PTJ
- AUQi, GB
Tang, YF
Shi, LL
Zhuang, JH
Liu, XL
Liu, B
- AFGuobin Qi
Yufu Tang
Leilei Shi
Jiahao Zhuang
Xianglong Liu
Bin Liu
- TICapsule Shedding and Membrane Binding Enhanced Photodynamic Killing of Gram-Negative Bacteria by a Unimolecular Conjugated Polyelectrolyte
- SONANO LETTERS
- LAEnglish
- DTArticle
- DECapsule Shedding; Membrane Binding; Energytransfer; Gram-negative Bacteria; Photodynamic Antimicrobialtherapy
- IDENERGY-TRANSFER; PEPTIDES; MECHANISMS; RESISTANCE
- ABThe development of new antimicrobial agents to treat infections caused by Gram-negative bacteria is of paramount importance due to increased antibiotic resistance worldwide. Herein, we show that a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte (PorHP) exhibits high photodynamic bactericidal activity against the Gram-negative bacteria tested, including a multidrug-resistant (MDR) pathogen, while demonstrating low cytotoxicity toward mammalian cells. Comprehensive analyses reveal that the antimicrobial activity of PorHP proceeds via a multimodal mechanism by effective bacterial capsule shedding, strong bacterial outer membrane binding, and singlet oxygen generation. Through this multimodal antimicrobial mechanism, PorHP displays significant performance for Gram-negative bacteria with >99.9% photodynamic killing efficacy. Overall, PorHP shows great potential as an antimicrobial agent in fighting the growing threat of Gram-negative bacteria.
- C1[Qi, Guobin; Tang, Yufu; Zhuang, Jiahao; Liu, Xianglong; Liu, Bin] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore.
[Shi, Leilei] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai 201600, Peoples R China. [Zhuang, Jiahao; Liu, Xianglong; Liu, Bin] Tianjin Univ Fuzhou, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Binhai New City 350207, Fuzhou, Peoples R China. [Liu, Bin] Natl Univ Singapore, Inst Funct Intelligent Mat, Singapore 117544, Singapore - C3National University of Singapore; Shanghai Jiao Tong University; TJU-NUS Joint Institute; National University of Singapore; Institute for Functional Intelligent Materials (I-FIM)
- RPLiu, B (corresponding author), Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore; Liu, B (corresponding author), Tianjin Univ Fuzhou, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Binhai New City 350207, Fuzhou, Peoples R China; Liu, B (corresponding author), Natl Univ Singapore, Inst Funct Intelligent Mat, Singapore 117544, Singapore
- FUNational Research Foundation Singapore [E-467-00-0012-02]; National University of Singapore [R279-000-444-281, R279-000-483-281]; Singapore National Research Foundation [22105229]; National Natural Science Foundation of China
- FXThis study is supported by the National University of Singapore (R279-000-482-133), the Singapore National Research Foundation (R279-000-444-281 and R279-000-483-281), National University of Singapore (E-467-00-0012-02), and the National Natural Science Foundation of China (22105229).
- NR47
- TC3
- Z93
- U118
- U234
- PUAMER CHEMICAL SOC
- PIWASHINGTON
- PA1155 16TH ST, NW, WASHINGTON, DC 20036 USA
- SN1530-6984
- J9NANO LETT
- JINano Lett.
- PDNOV 3
- PY2023
- VL23
- BP10374
- EP10382
- DI10.1021/acs.nanolett.3c02965
- PG9
- WCChemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
- SCChemistry; Science & Technology - Other Topics; Materials Science; Physics
- GAY9PO2
- UTWOS:001108509100001
- ER
- EF
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