People

Title

Professor

Degree

PhD University of Cambridge, UK
BEng in Mechanical Engineering (with First Class Honours), National University of Singapore

Research Interests

Microfluidic technology for biomedical applications, Flexible wearable sensors, Nanobiomaterials

Office Location

E3, #05-10, 9 Engineering Drive 1 Dept of Biomedical Engineering National University of Singapore Singapore 117581

Biography

Professor Chwee Teck Lim is the NUS Society Chair Professor of Biomedical Engineering and Director of the Institute for Health Innovation and Technology at NUS. His research interest is in the development of innovative biomaterials and health technologies for biomedical applications. He is a prolific researcher having co-authored over 420 journal publications and given more than 400 plenary/keynote/invited talks.  He is also a serial entrepreneur having started six companies to commercialize technologies developed in his lab. Prof Lim is globally recognized for his distinguished academic achievements as is evidenced by his elected fellowship at the US National Academy of Inventors, American Institute for Medical & Biological Engineering, International Academy for Medical & Biological Engineering, ASEAN Academy of Engineering and Technology, Academy of Engineering, Singapore and Singapore National Academy of Science. He and his team have garnered over 100 research awards and honours including Asia’s Most Influential Scientist, Highly Cited Researcher, IES Prestigious Engineering Achievement Award, ASEAN Outstanding Engineering Achievement Award, Asian Scientists 100, Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) and the President’s Technology Award among others.

Selected Publications

• Chakraborty S, et al, Agrin-Matrix Metalloproteinase-12 axis confers a mechanically competent microenvironment in skin wound healing, Nature Communications, 12, 6349, 2021.
• Gao, YJ, et al, A wearable multifunctional immunosensor for the monitoring of chronic wounds, Science Advances, 7, 21, eabg9614, 2021.
• Phuong Le, et al, Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion, Nature Communications, 12,397,2021
• Jain, S et al, The role of single cell mechanical behavior and polarity in driving collective cell migration, Nature Physics, 1-8, 2020.
• Sun, AXY, et al,  Potassium channel dysfunction in human neuronal models of Angelman syndrome, Science, 366, 6472, 1486-1492, 2019.
• Lim, SB et al, Addressing cellular heterogeneity in tumor and circulation for refined prognostication, PNAS, 116, 36, 17957-17962, 2019.
• Xi, W et al, Material Approaches to Active Tissue Mechanics, Nature Reviews Materials, 4, 23–44, 2019.
• Saw, TB et al, Biological tissues as active nematic liquid crystals, Advanced Materials, 30, 47, 2018.
• Chaudhuri, PK et al, Mechanobiology of Tumor Growth, Chemical Reviews, 118, 14, 6499-6515, 2018.
• Khoo, BL et al, Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device, Nature Protocols, 13, 34-58, 2018.
• Lim, SB et al, An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer, Nature Communications, 8, 1734, 2017.
• Xi, W et al., Soft tubular microfluidics for 2D and 3D applications, PNAS, 114, 40, 10590–10595, 2017.
• Saw, TB et al, Topological defects in epithelia govern cell death and extrusion, Nature, 544, 212-216, 2017.
• Warkiani, ME, et al, Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics, Nature Protocols, 14, 1, 128-37, 2016.
• Vedula, SRK et al, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111, 2015.
• Vedula, SRK et al, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96, 2014.