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@article{WOS:001666014800001,
title = {Spontaneously N-Doped Conjugated Polyelectrolyte Coatings Accelerate
Electron Uptake in Shewanella Oneidensis},
author = {Zhongxin Chen and Yilu Song and Samantha R McCuskey and Jianan Cai and Weidong Zhang and Nansi Zhou and David Ohayon and Fernando Lopez-Garcia and Alexey I Berdyugin and Xianwen Mao and Guillermo C Bazan},
doi = {10.1002/adma.202521386},
times_cited = {0},
issn = {0935-9648},
year = {2026},
date = {2026-02-01},
journal = {ADVANCED MATERIALS},
volume = {38},
number = {12},
publisher = {WILEY-V C H VERLAG GMBH},
address = {POSTFACH 101161, 69451 WEINHEIM, GERMANY},
abstract = {Bioelectrochemical systems interconvert electrical and chemical energy
using living microorganisms, but their efficiency remains limited by
slow electron exchange across abiotic-biotic interfaces. Herein, a
spontaneous n-doped water-dispersible conjugated polyelectrolyte (CPE),
PNB, is developed. The CPE self-assembles on the surface of Shewanella
oneidensis MR-1 to create biocompatible coatings that accelerate inward
extracellular electron transfer. PNB is obtained via an aldol
condensation reaction and is described by an acceptor-acceptor
pi-conjugated backbone bearing quaternary ammonium side chains. This
molecular architecture enables stable n-doping in aqueous media and a
broad reduction potential window. When integrated as a cathodic
interlayer, PNB-S. oneidensis biohybrids exhibit a 14-fold enhancement
in electron injection and a 4-fold increase in electro-driven succinate
production, compared to unmodified cells. Single-cell electrochemical
mapping confirms faster, more efficient per-cell electron influx. These
findings demonstrate that n-type CPEs can bridge external electrodes
with cellular metabolisms, opening a material-based route to
high-performance bioelectronic and electrosynthetic systems. By enabling
more facile charge transfer between synthetic semiconductors and living
catalysts, this work establishes a soft materials-driven framework for
designing electronically coupled microbial systems with potential to
advance sustainable bioelectronic technologies.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{WOS:001644445400001,
title = {Conjugated polyelectrolyte-aptamer hybrid for
organic-electrochemical-transistor-based sensing},
author = {Yan Jiang and David Ohayon and Benjamin Rui Peng Yip and Glenn Quek and Zhongxin Chen and Guillermo C Bazan},
doi = {10.1016/j.xcrp.2025.102965},
times_cited = {0},
year = {2025},
date = {2025-12-01},
journal = {CELL REPORTS PHYSICAL SCIENCE},
volume = {6},
number = {12},
publisher = {CELL PRESS},
address = {50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA},
abstract = {Organic mixed ionic-electronic conductors (OMIECs) are promising
materials for bioelectronic applications due to their ability to
simultaneously transport ions and electronic charges. However, achieving
selective recognition without compromising desirable mixed transport
characteristics in a single material remains a challenge. In response,
we report an electron-transporting (n-type) conjugated polyelectrolyte
(CPE) with carboxybetaine-functionali zed side chains, which allow for
the covalent attachment of amino-terminated aptamers to form a
CPE-aptamer hybrid, namely, p(NDI-T-ZI/EG)-aptamer. When employed as the
channel material in organic electrochemical transistors (OECTs), the
resulting p(NDI-T-ZI/EG)-aptamer hybrid can maintain mixed conduction
and amplify the signal of aptamers. Meanwhile, it shows high specificity
in dopamine (DA) recognition across a wide concentration range, from
attomolar to nanomolar range. Mechanistic studies revealed that target
binding induces aptamer contraction, modulating charge density and
channel capacitance. These findings demonstrate the potential of
aptamer-based OECT sensing for next-generation decentralized
bioelectronic diagnostics and personalized healthcare.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{WOS:001557471100001,
title = {Aqueous asymmetric pseudocapacitor featuring high areal energy and power
using conjugated polyelectrolytes and
Ti3C2Tx MXene},
author = {Benjamin Rui Peng Yip and Chaofan Chen and Yan Jiang and David Ohayon and Guillermo C Bazan and Xuehang Wang},
doi = {10.1038/s41467-025-63034-9},
times_cited = {19},
year = {2025},
date = {2025-08-01},
journal = {NATURE COMMUNICATIONS},
volume = {16},
number = {1},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Despite the development of various pseudocapacitive materials, full-cell
pseudocapacitors have yet to surpass the power density of conventional
electric double layer capacitors, primarily due to the lack of high-rate
positive pseudocapacitive materials. This work reports a solid-state
conjugated polyelectrolyte that achieves high-rate charge storage as a
positive electrode, facilitated by a co-ion desorption mechanism. The
conjugated polyelectrolyte retains 70% of its capacitance at 100 A g-1
with a mass loading of 2.8 mg cm-2 and exhibits a long cycling life of
100,000 cycles in a Swagelok cell configuration. Increasing the
electrode thickness fourfold has minimal impact on ion diffusivity and
accessibility, yielding a high areal capacitance of 915 mF cm-2. When
paired with a high-rate negative pseudocapacitive electrode Ti3C2Tx, the
device leverages the redox-active potentials of both materials,
achieving a device voltage of 1.5 V and supports operation rates up to
10 V s-1 or 50 A g-1. This configuration enables the pseudocapacitor to
deliver an areal power of 160 mW cm-2, while significantly increasing
the areal energy (up to 71 mu Wh cm-2). The high areal performance,
combined with the additive-free and water-based fabrication process,
makes pseudocapacitors promising for on-chip and wearable energy storage
applications.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{WOS:001524882400050,
title = {Three-dimensional conductive conjugated polyelectrolyte gels facilitate
interfacial electron transfer for improved biophotovoltaic performance},
author = {Zhongxin Chen and Samantha R McCuskey and Weidong Zhang and Benjamin Rui Peng Yip and Glenn Quek and Yan Jiang and David Ohayon and Shujian Ong and Binu Kundukad and Xianwen Mao and Guillermo C Bazan},
doi = {10.1038/s41467-025-61086-5},
times_cited = {13},
year = {2025},
date = {2025-07-01},
journal = {NATURE COMMUNICATIONS},
volume = {16},
number = {1},
publisher = {NATURE PORTFOLIO},
address = {HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY},
abstract = {Living biophotovoltaics represent a potentially green and sustainable
method to generate bio-electricity by harnessing photosynthetic
microorganisms. However, barriers to electron transfer across the
abiotic/biotic interface hinder solar-to-electricity conversion
efficiencies. Herein, we report on a facile method to improve
interfacial electron transfer by combining the photosynthetic
cyanobacterium Synechococcus elongatus PCC 7942 (S. elongatus) with a
conjugated polyelectrolyte (CPE) atop indium tin oxide (ITO)
charge-collecting electrodes. By self-assembly of the CPE with S.
elongatus, soft and semitransparent S. elongatus/CPE biocomposites are
formed with three-dimensional (3D) conductive networks that exhibit
mixed ionic-electronic conduction. This specific architecture enhances
both the natural and mediated exoelectrogenic pathway from cells to
electrodes, enabling improved photocurrent output compared to bacteria
alone. Electrochemical studies confirm the improved electron transfer at
the biotic-abiotic interface through the CPE. Furthermore, microscopic
photocurrent mapping of the biocomposites down to the single-cell level
reveals a similar to 0.2 nanoampere output per cell, which translates to
a 10-fold improvement relative to that of bare S. elongatus,
corroborating efficient electron transport from S. elongatus to the
electrode. This synergistic combination of biotic and abiotic materials
underpins the improved performance of biophotovoltaic devices, offering
broader insights into the electron transfer mechanisms relevant to
photosynthesis and bioelectronic systems.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}

@article{WOS:001461023800001,
title = {Impact of Noncompensating Ions on the Electrochemical Performance of
n-Type Polymeric Mixed Conductors},
author = {David Ohayon and Amer Hamidi-Sakr and Jokubas Surgailis and Shofarul Wustoni and Busra Dereli and Nimer Wehbe and Stefan Nastase and Xingxing Chen and Iain Mcculloch and Luigi Cavallo and Sahika Inal},
doi = {10.1021/jacs.4c17579},
times_cited = {13},
issn = {0002-7863},
year = {2025},
date = {2025-04-01},
journal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},
volume = {147},
number = {15},
pages = {12523-12533},
publisher = {AMER CHEMICAL SOC},
address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
abstract = {Organic mixed ionic-electronic conductors (OMIECs) have emerged as
essential materials for applications in bioelectronics, neuromorphics,
and energy storage, owing to their ability to transport both ions and
electrons. While significant progress has been made in understanding
their operation, the role of noncompensating ions in polymer redox
processes remains underexplored, particularly in the context of their
impact on charge compensation and device performance. In this study, we
systematically investigate the influence of noncompensating ions on the
performance of n-type OMIECs with and without polar side chains,
focusing on their interactions with electrolytes containing anions from
the Hofmeister series. Our findings reveal a stark contrast in charging
behavior and organic electrochemical transistor (OECT) performance based
on side-chain chemistry. Polar oligoether side chains promote
interactions with anions, resulting in significant performance
variations. We demonstrate the critical role of polymer side-chain
interactions with the different anions, where polyatomic anions capable
of infiltrating the film degrade device performance, particularly in
terms of transconductance and operational stability. In contrast, OMIECs
without side chains exhibit performance independent of the
noncompensating ion nature. Through electrochemical analysis,
spectroscopic techniques, and molecular dynamics simulations, we provide
a comprehensive understanding of how ion incorporation and
polymer-electrolyte interactions shape device behavior. This study
highlights the transformative role of side-chain functionality in
tailoring the properties of the OMIEC and offers a design framework for
high-performance OECTs, enabling advancements in biosensing,
neuromorphic computing, and beyond.},
keywords = {},
pubstate = {published},
tppubtype = {article}
}