ABSTRACT
We recently depicted the “Nano-immunity-by-design” where the characterization of 2D materials is not solely based on their physical-chemical parameters but also on their immuneprofiling. [1] The immune-profiling can reveal its complexity in unique, informative ways: high-dimensional approaches. [2,3] We pioneered the development of high-dimensional analyses, such as single-cell mass cytometry and imaging mass cytometry on graphene and other novel two-dimensional materials, such as transition metal carbides/carbonitrides (MXenes). [4-6] We revealed that the amino-functionalization of graphene oxide increased its immunocompatibility. [4] Moreover, we combined graphene with AgInS2 nanocrystals, enabling its detection by single-cell mass cytometry on a large variety of primary immune cells. [5] Recently, we reported the immune modulation of specific MXenes, together with their label-free detection by single-cell mass cytometry in cells and tissues. [6-7] Moreover, I will present unpublished results on various 2D materials MoS2, WS2, and bismuthene. Our results conceptualize that chemical and high-dimensional immunological designs of 2D materials offer new technological platforms in biomedicine.
BIOGRAPHY
Prof. Lucia Gemma Delogu currently serves as the Head of the ImmuneNano-Lab at the University of Padua in Italy and is a visiting Associate Professor at New York University Abu Dhabi. Her expertise in the field of Immunology and Material Science was acquired during her time at the University of Southern California in the United States and at the Technische Universität Dresden in Germany. Prof. Delogu has also acted as the Scientific Coordinator for four interdisciplinary EU projects and has been recognized with multiple awards, including the “Marie S. Curie Individual Fellow”. Her pioneering work has focused on the use of high-dimensional single-cell approaches in relation to carbon-based and 2D nanomaterials. Her current research is primarily focused on examining the biological interactions of 2D nanomaterials and nanoparticles and their potential for immunomodulation in biomedical applications.
References
[1] Gazzi A et al… and Delogu LG*. Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-bydesign. J Phy Mat (2020).
[2] Fusco L et al… and Delogu LG*. Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics. Theranostics (2020).
[3] Weiss C et al… and Delogu LG*. Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic. ACS Nano (2020)
[4] Orecchioni M et al… and Delogu LG*. Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells. Nature Communications (2017).
[5] Orecchioni M et al… and Delogu LG*. Toward High-Dimensional Single-Cell Analysis of Graphene Oxide Biological Impact: Tracking on Immune Cells by Single-Cell Mass Cytometry. Small (2020).
[6] Unal MA et al. and Gogotsi Y*, Delogu LG*, Yilmazer A*. Nanotoday (2021).
[7] Fusco L, Gazzi A et al. and et al. and Gogotsi Y*, Delogu LG*, Advanced Materials (2022).